Lengthy but strenuous (option 1) or moderate (option 2) loop with very long single track descent.
Begin at Upper Oso
Ascend Big Pine Road
Descend Buckhorn Trail to Mono (single track)
1) Cross Santa Ynez River and return to Upper Oso via Gibraltar Mine
or
2) Ascend Camuesa Road; descend Big Pine Road; descend Camuesa Connector
6-8 hr
Untreated water is available at Mono debris dam and half way up the Camuesa Road